As the calendar marks September 17, 2026, the Detroit Lions gear up for a challenging away game against the Buffalo Bills at Highmark Stadium.

The Lions head to Orchard Park with determination and the goal to capture early-season momentum. This game presents a significant challenge as they face off against a formidable Bills squad in this anticipated matchup.

The Bills, hosting the contest, will look to leverage their home advantage and showcase their strengths. Both teams aim to dictate the pace and emerge with a victory, making this game crucial for setting the tone for the rest of their seasons.

Betting lines: Buffalo Bills -4.50, Detroit Lions 4.50. Total: 53.50. Moneyline: Buffalo Bills -218, Detroit Lions 180. (DraftKings)

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